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KMID : 0043320110340030423
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Archives of Pharmacal Research
2011 Volume.34 No. 3 p.423 ~ p.436
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Anti-metastatic properties of the leaves of Eriobotrya japonica
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Cha Dong-Seok
Shin Tae-Yong
Eun Jae-Soon
Kim Dae-Keun
Jeon Hoon
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Abstract
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The leaves of Eriobotrya japonica Lindl. have been widely used as a traditional medicine for the treatment of many diseases including gastroenteric disorders, diabetes mellitus, chronic bronchitis and asthma. In the present study, the anti-metastatic action of the EtOAc fraction of the leaves of E. japonica (LEJ) was investigated. LEJ showed potent inhibitory effects on MMP-2 and MMP-9 activities and expressions via down-regulation of NF-κB translocation to the nucleus in B16F10 cells. In addition, the cell migration and invasion were down-regulated by LEJ. LEJ also significantly suppressed lung metastasis in vivo. Moreover, we isolated the compounds ursolic acid and 2α-hydroxyursolic acid from LEJ and both compounds also significantly suppressed MMP-2 and MMP-9 activities, indicating that they are the active components of LEJ. The present results demonstrate that LEJ may be used as valuable antimetastatic agent for the treatment of cancer metastasis.
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KEYWORD
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Eriobotrya japonica, Matrix metalloproteinase, Cancer metastasis
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